Jakarta, TOPNews Indonesia –
Vaccination program covid-19 is still running today. Vaccines are expected to help create antibodies in the body that can prevent severe and severe infections if tested positive for Covid-19. However, there are reasons for antibodies not forming after the vaccine.
How can vaccines protect the body?
Citing the WHO page, the vaccine protects by inducing an effector mechanism (cell or molecule) capable of rapidly controlling pathogen replication or deactivating its toxic components.
It’s just that the next question is, is it possible that antibodies will not form after vaccination?
Citing the journal Human Vaccines and Immunotherapeutics, about 2-10 percent of people experience non-responding antibodies or fail to form antibodies.
The term non-responsiveness or primary vaccination failure is currently defined as the inability of the host or vaccine provider to mount a sufficient protective antibody response after primary or booster vaccination.
The general definition of vaccination failure is based on 2 aspects; vaccine and host related factors. Temporary vaccine shortages (such as incomplete attenuation, wrong immunization route or schedule, or failure of vaccine delivery.
The journal also revealed that there are 2 main factors that cause antibodies not to form after the vaccine.
These primary factors are associated with failed vaccine attenuation, incorrect immunization schedules, or vaccine administration. In the context of this primary factor, it is characterized by loss of early age protection effectiveness.
Meanwhile, secondary factors are associated with a person’s genetic factors, immune status, age, health, and nutritional status.
Between the two factors that cause antibodies not formed after this vaccine, primary factors can be overcome through logistical improvements. But factors secondary to non-responders are more difficult to “control.”
There are several properties of vaccines that affect the effectiveness of vaccines and also the reasons for not forming antibodies.
Complete description of primary and secondary factors
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